Minneapolis Regenerative Medicine Is One Of Minnesota's Leading Experts In Treating Joint Pain.
Minneapolis Regenerative Medicine provides the most advanced, innovative medical solutions to help get patients out of pain. We are Minnesota’s experts in dealing with joint pain and our doctors have treated thousands of patients with precise, customized care resulting in excellent outcomes of treatment.
Our Mission At Minneapolis Regenerative Medicine Is To Help The Local Twin Cities Communities Live Pain-Free.
We decided to accomplish this through a partnership with Ambiente Gallerie, one of the best downtown Minneapolis health and wellness clinics.
Together, we wanted to focus on finding a natural way to heal the body by utilizing the regeneration and healing processes that are encoded in our DNA. We were frustrated by the fact that the millions of adults experiencing joint pain had two options: 1) Disguise the pain or 2) Highly-Invasive surgical joint replacement. We did our research and we are here to tell you that THERE ARE OTHER OPTIONS!
Minneapolis Regenerative Medicine Provides A Revolutionary Treatment For Joint Pain.
Numerous advances in modern healthcare have increased the average human’s longevity but has also increased the percentage of people that deal with chronic conditions. Our treatment is based on innovative research that allows us to address conditions that were previously “permanent”. Regenerative medicine does not focus on masking the pain that results from degeneration (like these solutions “your options page”), but instead provide a way for you to help rejuvenate your aged cells and encourage your body to repair the degenerated tissue for long-term relief. Find out how HERE.
Mesenchymal Cells - As The "Gold Standard" Of Regenerative Medicine.
Many clinical trials have resulted in huge steps forward for global healthcare, but none have had the same healing potential of mesenchymal cells. These cells are known as the “gold standard” of regenerative medicine. Mesenchymal cells are multipotent adult cells that are present in many tissues, including umbilical cord, bone marrow and fat tissue. Mesenchymal cells can self-renew by dividing and can differentiate into multiple tissues including bone, cartilage, muscle and fat cells, and connective tissue. Find out how HERE.
Our Doctors At Minneapolis Regenerative Medicine Have Treated Thousands Of Patients With Excellent Outcomes Of Treatment.
Our doctors have over seven years of experience in orthopedics and have treated over 5,000 patients with regenerative medicine. We have seen fantastic results and want to continue to share our expertise in joint pain solutions with the Minneapolis/St. Paul community.
How Does Mesenchymal Cell Therapy Work?
When it comes to mesenchymal cell therapy, the most important factor is location. The cells cannot perform their healing tasks without being present at the site. In practice, these types of cells work best when they are injected directly into the affected site where they can quickly reach damaged tissue. From here, mesenchymal cells are able to help fulfill a variety of roles to regenerate your body.
How Do Our Doctors At Minneapolis Regenerative Medicine Locate Damaged Tissue?
However, these adhesion molecules in combination with a variety of endothelial cells allow the mesenchymal cells to migrate to different areas of the body. They utilize a process called ‘bind and roll’ as activated surface adhesion molecules (selectins) ‘bind’ to the endothelium and ‘roll’ along the membrane. Here, molecules on the surface, called G-protein coupled chemokine receptors, bind to SDF-1, a ligand that is triggered by the body’s inflammatory response. This causes the cell to change into a high affinity conformation for integrins. In response to activation by chemokine SDF-1, integrin VLA-4 is activated and binds to a ligand receptor VCAM-1(vascular cell adhesion molecule) on the surface of the endothelium. From here, the mesenchymal cell must travel transcellularly to get to the target tissue. Inflammatory cytokines released from damaged tissue activate matrix metalloproteinases which break down the endothelial membrane to allow the mesenchymal cell to move into the interstitial space. Finally, growth factors in the damaged tissue such as platelet-derived growth factor-AB and insulin-like growth factor-1 act as chemotactic signals that mesenchymal cells migrate toward. This causes the cell to finally cross the barrier and begin to regenerate tissue.
How Does Regeneration Actually Occur?
Mesenchymal cells have a variety of ways they can help healing to occur. The first is that they can differentiate into different cell types. For example, an arthritis patient who has lost cartilage in the joint space would likely have mesenchymal cells that can differentiate into chondrocytes to help begin production of a healthy cartilaginous matrix. Next, they can have the ability to directly replace damaged cells through cell fusion, combining with them and forming a healthy cell. When injected intravenously, the mesenchymal cell can act indirectly by secreting different paracrine factors that up-regulate cell production needed to help fix damaged tissue. They can also transfer organelles (via TNT (tunneling nano-tube)) to different target cells such as mitochondria (organelle that produces energy for cells) or other needed molecules such as ions, peptides, or proteins. Lastly, mesenchymal cells can help moderate the transfer of molecules, hormones, and ions via exosomes and micro-vesicles.
Ullah, M., Liu, D., & Thakor, A. (2019, May 09). Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement. Retrieved August 12, 2020, from https://www.sciencedirect.com/science/article/pii/S2589004219301415
Spees, J., Lee, R., & Gregory, C. (2016, August 31). Mechanisms of mesenchymal stem/stromal cell function. Retrieved August 12, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007684/